SARM MK-677 Ibutamoren is an oral anabolic-catabolic product based on(R)-1'-(2-methylalanyl-O-Benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine], a chemical compound commonly known as Ibutamoren or MK-677. It mimics ghrelin, the action of which can increase growth hormone (GH, somatotropin) and insulin-like growth factor 1 (IGF-1) and reducing a cortisol level in the organism.
- It has strong anabolic properties
- Facilitates the loss of excessive body fat
- Effectively inhibits catabolism
- Increases the concentration of somatotropin and IGF-1
- Reduces levels of cortisol
- Is a ghrelin mimetic
- Is a safe alternative to the injection of growth hormone
- Supports the development and preservation of muscles
- Shortens regeneration of the organism
Ibutamoren, by acting on the growth hormone receptors (GHS-R) can increase the concentration of GH, IGF-1, and the proteing being necessary for the proper functioning and binding insulin-like growth factor-3 (IGFBP-3). The capability of activating GHS-R has been attributed so far, only to grehlin. The imitation of ghrelin in this area allowed to classify the substance as a ghrelin mimetic.
An adequately high level of growth hormone is responsible for a number of important body processes, including: the development of the system, energy substrates economy, the intensity of anabolic and catabolic changes, immune response and the functionig of the central nervous system.
Regulating the secretion of somatotropin is the role of somatoliberin, somatostatin and IGF-1, and among stimuli that increase its secretion, the most frequently mentioned are: physical effort, sleep, the supply of appropriate amino acids, hunger and the accompanying ghrelin, as well as the availability of some other hormones. GH ejection leads to increased binding process of amino acids by muscle tissues, synthesis and regeneration of muscle fibers, strengthening the structure of the skeleton and reducing fat.
Ibutamoren unlike ghrelin does not raise the level of cortisol and even reduces it. It has no impact on the amount of prolactin and luteinising hormone (LH). It may slightly decrease testosterone level in total, but without major impact on the ratio of free testosterone. Thus, MK-677 is able to induce positive effects attributed to grehlin, without showing its negative properties.
MK-677 is characterized by degradation resistance as a rsult of a contact with the acid environment of the digestive system – thanks to that, it exhibits high stability and very good bioavailability. An oral form of the product makes tahat ibutamoren becomes a highly valuable alternative to the synthetic growth hormone used in the problematic form of injection.
Directions: As and adult dietary supplement, take 1 capsule twice daily with meals (20mg per day for 6-8 weeks). Do not exceed more that 2 capsules in a 24 hour period of time.
Product Warnings: Consult your physician prior to use if you have or are at risk of high blood pressure, heart, kidney, thyroid, prostate or psychiatric disease, including anxiety, depression, seizure disorders, strokes or any other medical conditions. Do not use this product if you have been diagnosed with androgen-sensitive cancers, high cholesterol or hypertiension. Consult your physician prior to use if you are taking any other medications. Do not exceed the suggested dosage of two capsules in any single given 24 hours period of time. Discontinue use if you experience rapid heartbreaks, dizziness, vomiting, or other similar symptoms. This product should not be taken by women. Keep out of reach from children.
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